Targets for glycated haemoglobin
نویسندگان
چکیده
منابع مشابه
Glycated Haemoglobin: A Predictor of Vascular Risk?
Glycated haemoglobin (HbA1c), a marker of average glycaemia during the previous six to eight weeks, is a predictor of microvascular complications in diabetic individuals. However, the role of HbA1c as a predictor of macrovascular complications (e.g. myocardial infarction or stroke) in these patients is not clearly defined. In contrast, new evidence suggests that HbA1c can predict the risk of ca...
متن کاملLabile glycated haemoglobin and carbamylated haemoglobin are still critical points for HbA1c measurement
INTRODUCTION Haemoglobin A1c (HbA1c) is a key analyte for the monitoring of glycemic balance in diabetic patients and is used for diabetes diagnosis in many countries. The potential interference of carbamylated haemoglobin (cHb) and labile glycated haemoglobin (LA1c) on HbA1c assays must remain a matter of vigilance. Such a situation has occurred in our laboratory with a kit replacement on the ...
متن کاملd-Ribose as a Contributor to Glycated Haemoglobin
Glycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that d-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with d-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant of fructosamine formation for d-ribose was approximately 60 times higher than that ...
متن کاملArtifactually low glycated haemoglobin in a patient with severe hypertriglyceridaemia.
This report describes a case of artifactually low glycated haemoglobin (Hb) in a patient with type II diabetes and severe hypertriglyceridaemia. The effect of hypertriglyceridaemia on glycated Hb determination using the Abbott Vision method was investigated in a series of patients with diabetes. The interference of triglycerides in glycated Hb assays was also investigated by two other methods, ...
متن کاملAberrantly high glycated haemoglobin measurement due to the haemoglobin variant Hb Santa Juana.
Various laboratory and patient-related factors can result in falsely high or low glycated haemoglobin (HbA1c) measurements, and haemoglobin (Hb) variants that interfere with laboratory readings is an important cause of this. We report a case of a rare Hb variant, Hb Santa Juana, manifesting as a falsely high HbA1c in a 62-year-old patient with type 2 diabetes mellitus. The patient presented wit...
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ژورنال
عنوان ژورنال: BMJ
سال: 1995
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.311.6998.189b